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How to Choose the Best ADHD Medication for Adults With Anxiety and Depression If a person is suffering from both ADHD and anxiety or depression, addressing the first disorder can help the second. Mental health professionals often prescribe antidepressants or a stimulant for depression along with an ADHD medication. Wellbutrin (bupropion), and Effexor, (venlafaxine), are the two most common antidepressants that are prescribed for ADHD "off-label". These drugs increase the levels of neurotransm