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05). There was a significant decrease in ADA in GCF and significant increases in CAT and GSH levels after SRP (p less then 0.05) in all four groups. The groups that were administered only gel (2nd and 4th) were different from other groups in terms of ADA, CAT, and GSH levels at 1st week (p less then 0.05). Conclusion HA application as an adjunct to SRP did not affect the clinical results, although, in the control sessions following the application, the results were favorable for the biochemical data in gel-applied groups. Trial registrat