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The model could be used in the study of the interaction between respiratory and cardiovascular systems in pathophysiological conditions.Fuzzy set theory and a series of theories derived from it have been widely used to deal with uncertain phenomena in multi-criterion decision-making problems. However, few methods except the Z-number considered the reliability of information. In this paper, we propose a multi-criterion decision-making method based on the Dempster-Shafer (DS) theory and generalized Z-numbers. To do so, inspired by the con