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The Most Effective ADHD Medication For Adults Stimulants are the first choice of medication for adults with ADHD. They assist in adjusting the levels of two chemical messengers in the brain that regulate attention. The most effective adhd medication for adults is Strattera (atomoxetine). It is available in capsules that can be taken with food or without food. It is suitable for the majority of people. It lasts longer than stimulants that have a shorter duration of action lik