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Furthermore, it absolutely was uncovered that OsCERK1 lowers the threshold to CuO NPs stress by managing the anti-oxidant system and enhancing the accumulation of H2O2 in rice. In inclusion, CuO NPs therapy notably enhances the basal weight against M. oryzae which will be mediated by OsCERK1. In conclusion, this research demonstrated a dual part of OsCERK1 in response to CuO NPs stress and M. oryzae infection by modulating ROS buildup, which expands our understanding about the crosstalk bet