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may serve as effective chemosensitizers for cancer therapy. This study aims at evaluating the metrics of glycemic control in people with type 1 diabetes using the hybrid closed loop (HCL) system during the COVID-19 lockdown. This is a retrospective study of thirty adults with type 1 diabetes using HCL and followed with telemedicine at an Italian University Hospital. Data on metrics of glucose control were collected at different times two weeks before the lockdown (Time , first two weeks of lockdown (Time 1), last two weeks of lockdown (