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This work also highlighted the importance of ligand density for tumor targeting. Hepatic stellate cells (HSC) activation and proliferation mediated the pathogenic development of hepatic fibrosis (HF). However, the underlying mechanisms remain poorly understood. In this study, we aimed to investigate the miR-29a-3p and its effects on PIK3R3 expression in HF pathogenesis. LX-2cells treated with TGF-β1 was used as the invitro HF model. The expression of microRNAs and proteins in LX-2cells were detected by quantitative RT-PCR and western bl