https://www.selleckchem.com/pr....oducts/bzatp-triethy
Assembly of the heteromeric complex was demonstrated invitro and invivo using samples from mouse and human origin. The CCR9DRD5 heteroreceptor was upregulated in the intestinal mucosa of IBD patients. Signaling assays confirmed that complexes behave differently than individual receptors. Remarkably, the disruption of CCR9DRD5 assembly attenuated the recruitment of CD4 T cells into the colonic mucosa. Our findings describe a key homing receptor involved in gut inflammation and introduce a new cell surface module in im
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