https://www.selleckchem.com/pr....oducts/pci-34051.htm
Transwell migration and MTS findings showed that si-SphK1 transfection (si-SphK1 group) could reduce migration quantity and cell viability of colon cancer cells compared to negative control (NC) (p0.0001). SphK1 inhibition (si-SphK1 group) significantly down-regulated S1PR1 and S1PR3 gene transcription in SW480 and HT-29 cells (p0.0001), and decreased activation level of JAKSTAT3 signaling pathway compared to NC group (p0.05). Over-expression of S1PR1 reversed inhibitory effects of si-SphK1 on migration/proliferation of SW
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