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Combined treatment with LCD did not lead to an additive increase in blood β-ketone levels. SGLT2 inhibitors and LCD exert differential effects on the body. Their combined use may achieve better metabolic improvements in obesity and type 2 diabetes. SGLT2 inhibitors and LCD exert differential effects on the body. Their combined use may achieve better metabolic improvements in obesity and type 2 diabetes. Tight control of hyperglycemia reduces risk of diabetic retinopathy (DR), but the residual risk remains high. This study ai