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The SIP was effective in metalworkers with WRSDs. Individual factors may influence the course of the disease and the need for the TIP. The SIP was effective in metalworkers with WRSDs. Individual factors may influence the course of the disease and the need for the TIP.Discordance between the mitochondrial and nuclear genomes is a prevalent phenomenon in nature, in which the underlying processes responsible are considered to be important in shaping genetic variation in natural populations. Among the evolutionary processes that best expla