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In aged 3 × Tg-AD mice, immunotherapy with all the 12×(Aβ1-15-Th) vaccine could prevent Aβ-induced decrease of synaptic proteins, which advised it features neuroprotective impacts in the mind. CONCLUSION The novel recombinant 12×(Aβ1-15-Th) chimeric vaccine targeting of pathological conformations of Aβ oligomers shows apparent neuroprotective advantages in preclinical advertisement model mouse, which suggests it is a good prospect vaccine when it comes to prophylaxis of adv