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This study aimed to identify the predictors and threshold of failure in neonatal acute respiratory distress syndrome. Newborns with severe acute respiratory distress syndrome aged 0-28 days and gestational age ≥36 weeks were included in the study if their cases were managed with non-extra corporal membrane oxygenation (ECMO) treatments. Patients were divided into two groups according to whether they died before discharge. Predictors of non-ECMO treatment failure were sought, and the threshold of predictors was calculated. A total of 10