https://www.selleckchem.com/pr....oducts/vps34-inhibit
Rationale Noonan syndrome (NS) is one of the most frequent genetic disorders. Bleeding problems are among the most common, yet poorly defined complications associated with NS. A lack of consensus on the management of bleeding complications in NS patients indicates an urgent need for new therapeutic approaches. Objective Bleeding disorders have recently been described in NS patients harboring mutations of LZTR1, an adaptor for CULLIN3 ubiquitin ligase complex. Here, we assessed the pathobiology of LZTR1-mediated bleeding disord
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