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But not every one of the fundamental mechanisms of ANXA8 upregulation are elucidated, the interdependence of RA-RARA and ANXA8 appears to play a relevant role in a few regular and tumorigenic configurations.Anti-fibrotic treatments are of increasing interest to fight cardiac remodeling and heart failure development. Recently, anti-fibrotic circular RNAs (circRNAs) are identified in real human and rodent cardiac tissue. In vivo (rodent) experiments proved cardia