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ess. It is opportune to further investigate AI in OCSG for early psychological intervention as an adjunct to conventional intervention programs.RATIONALE, AIMS AND OBJECTIVES In recent years, the use of proton pump inhibitors (PPI), especially omeprazole, has been associated with development of chronic kidney disease (CKD). These drugs are widely used worldwide. Although some studies have found an association between the use of PPI and the onset of acute renal failure and CKD. This study aims to analyze the association between the cont