https://integrasesignal.com/in....dex.php/metabolism-r
We show that in patient samples plus in the T-cell lines TMEM244 phrase is negatively correlated aided by the methylation standard of its promoter. Furthermore, we display that TMEM244 phrase can be activated in vitro because of the CRISPR-dCas9-induced specific demethylation of TMEM244 promoter region. Since both, TMEM244 appearance and its own promoter demethylation, are not recognized in normal lymphoid cells, they can be possibly utilized as markers in Sézary syndrome and other
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