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[Journal of Psychosocial Nursing and Mental Health Services, 59(2), 17-24.]. The effect of weight change patterns on cardiovascular diseases (CVD) remains uncertain. We aim to examine the relation of weight change patterns and absolute weight change from young adulthood to midlife with incident CVD. Retrospective cohort study. National Health and Nutrition Examination Survey 1999-2016. A total of 20 715 US adults aged 40 through 79 with recalled weight at young adulthood (25 years) and midlife (10 years before baseline). CVD status was