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Copyright © 2020 Cold Spring Harbor Laboratory Press; all rights reserved.BACKGROUND AND OBJECTIVES The role of serotonin-norepinephrine reuptake inhibitors (SNRIs) in migraine prophylaxis has not been completely established. Current treatments for vestibular migraine (VM) are based on scarce evidence. We aimed to perform an updated review focusing on the efficacy and tolerability of SNRIs for migraine and VM prevention. METHODS We searched the PubMed, Web of Science, and Cochrane Library databases for relevant studies. The primary outcom