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OBJECTIVE The current study aims to investigate whether computer generated (CG) expressions of emotion evoke similar emotional appraisal processing in the lateral orbitofrontal cortex (lOFC) compared to real human expressions, as well as how speech cues would influence the processing. METHODS Functional near-infrared spectroscopy was used to measure the neural activations in the prefrontal cortex during emotion recognition task. Thirty normal participants were asked to view videos of dynamic facial expressions and selected the emotions