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This study aimed to find the optimal acceleration factor achievable with CS-SENSE for a clinical ankle protocol while maintaining comparable image quality. We explored the optimal acceleration achievable with factor CS-SENSE, for an ankle protocol with T2-weighted, PD-weighted TSE-Dixon (coronal, axial and sagittal) and T2-mapping (sagittal) sequences, on a 3 T MRI-scanner. This study contained three steps (1) phantom test, (2) pilot test on healthy volunteers, (3) anatomical assessment on a cohort of healthy volunteers and a quantitativ