https://www.selleckchem.com/pr....oducts/XL880(GSK1363
Indeed, we found that PDE1C populated the tips of newly forming LEPs in polarized HASMCs, and co-localized with ADCY8, the Ca2+ release-activated Ca2+ channel subunit, Orai1, the cAMP-effector, PKA, and an A-kinase anchoring protein, AKAP79. Since this polarization could allow PDE1C to control cAMP signaling in a hyper-localized manner, we suggest that PDE1C-selective therapeutic agents could offer increased spatial specificity in HASMCs over agents that regulate cAMP globally in cells. Similarly, such agents could a
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