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ts given these antiretroviral regimens and the trajectory of this weight gain over time, especially among women, require further study. USAID, Unitaid, South African Medical Research Council, ViiV Healthcare. USAID, Unitaid, South African Medical Research Council, ViiV Healthcare.We present a theoretical model that demonstrates the integral role chromosome organization and structural mechanics play in the spreading of histone modifications involved in epigenetic regulation. Our model shows that heterogeneous nucleosome positioning, and