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vide new possibility for individualized treatment of thyroid cancer patients. Copyright © 2020 Lv, Cao, Hu, Shen and Wu.MicroRNAs (miRNAs) are a class of important non-coding RNAs, which play important roles in tumorigenesis and development by targeting oncogenes or tumor suppressor genes. One miRNA can regulate multiple genes, and one gene can be regulated by multiple miRNAs. To promote the clinical application of miRNAs, two fundamental questions should be answered what's the regulatory mechanism of a miRNA to a gene, and which