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cells. The excellent performance of the probe makes it applying for the visualization detection of endogenous cysteine in living cells and tissues with obtaining satisfactory results.An alternative optical signal transduction mechanism for ion-selective optodes is proposed. The nanostructural sensors benefit from ion-selective reversing aggregation caused quenching yielding turn-on, bright and highly stable optical signals. Selective incorporation of analyte results in transformation of the polymer dye from aggregate to a micelle structu