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The micro-immunotherapy medicine (MIM) 2LARTH® goals cytokines taking part in inflammation. Aim The aim of this research is measure the effect of the MIM compared to vehicle in an in vivo type of RA, caused in mice after immunization with articular bovine kind II collagen. Practices car and MIM had been mixed in clear water (1 capsule in 100 ml) and 100 µl was given by gavage daily for a fortnight. To evaluate the severity of arthritis, wrist and foot width was determined, paw