https://www.selleckchem.com/pr....oducts/epacadostat-i
Herein, a remarkable conjugated bis-guanidinate (CBG) supported zinc hydride, [LZnH2 ; L=(ArHN)(ArN)-C=N-C=(NAr)(NHAr); Ar=2,6-Et2 -C6 H3 ] (I) catalyzed partial reduction of heteroallenes via hydroboration is reported. A large number of aryl and alkyl isocyanates, including electron-donating and withdrawing groups, undergo reduction to obtain selectively N-boryl formamide, bis(boryl) hemiaminal and N-boryl methyl amine products. The compound I effectively catalyzes the chemoselective reduction of various isocyanates, in
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