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options, including immunotherapy for metastatic colorectal cancer (CRC). 2020 Hepatobiliary Surgery and Nutrition. All rights reserved.One of the most common cancers worldwide, colorectal cancer (CRC) has been associated with significant morbidity and mortality and therefore represents an enormous burden to the health care system. Recent advances in CRC treatments have provided patients with primary and metastatic CRC a better long-term prognosis. The presence of synchronous or metachronous metastasis has been associated, however, with w