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The functionality is demonstrated by analyses of heavy matrix bioreactor samples. Overall, this innovation offers a more convenient installation of the interface, improved handling with an extended lifetime of the emitter tips and additional functions compared to previous approaches, while keeping the higher sensitivity of nanoflow CE-MS-coupling.Oxygen evolution and reduction reactions play a critical role in determining the efficiency of the water cycling (H2 O ⇔ H2 + 1 2 O2 ), in which the hydrogen serves as the energy carrier. That ca