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Right here we present conclusions regarding the role of TLRs in FLC-induced PTC damage. We revealed human kidney PTC cultures to κ and λ FLCs, and utilized mobile supernatants and pellets for ELISA and gene phrase researches. We also analyzed areas from Stat1-/- and littermate control mice treated with daily intraperitoneal treatments of a κ-FLC for 10 times. FLCs enhanced the appearance of TLRs 2, 4, 6 via HMGB1, a damage-associated molecular pattern. Countering TLRs
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