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The prevalence of transmitted drug resistance (TDR) was investigated among 178 patients with new diagnosis of HIV-1 infection (57% with B subtype) performed between 2017 and 2019. Overall, the global prevalence of TDR was 7.9% (NRTIs, 3.9%; NNRTIs, 3.4%; PIs, 2.8%, INSTIs, 0.9%). The most frequent mutations were T215S/I/D (3.4%) in the reverse transcriptase region and M46I/L (1.1%) in the protease region, while in the integrase region the E138K was present in one case (0.6%). This article is protected by copyright. All rights reserved.