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0001). Further GWEGI analyses observed significant MSDP-gene interaction effects at UNC80 gene for anxiety (p=9.09×10 ). LDSC did not detect significant genetic correlation between anxiety and smoking traits. Pathway analysis identified 19 significant pathways for anxiety, such as MANALO_HYPOXIA_UP (FDR=5.50×10 ), REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS (FDR=0.0304) and ONDER_CDH1_TARGETS_2_UP (FDR=0.0371). Our study results suggested the important impact of MDSP on the risk of anxiety in offspring, partly attributing to environment-gene i