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CP score increase exhibited a stronger correlation to normal liver volume irradiated than ALBI grade increase. LKB models for CP increase found values for the volume-effect parameter of a=0.06 for all patients and 0.02/0.09 when fit to photon/proton patients separately. Subset analyses for patients with superior initial liver function showed consistent dose-volume effects (a=0.1) and consistent dose-response relationships. CONCLUSIONS This study presents an update of liver NTCP models in the era of modern RT techniques using relevant end