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022).Also, elevated levels of IgM-anti-FcεRIα, but not of IgG or IgA against FcεRIα, were linked to low blood basophil(r = 0.414, P = 0.021) and eosinophil(r = 0.623, P less then 0.001) counts. Conclusions Increased serum levels of IgM-anti-FcεRIα are common in patients with CSU and linked to features of autoimmune CSU. The role and relevance of autoantibodies to FcεRIα in CSU can and should be further characterized in future studies, and our novel assay can help with this.The emergence and evolution of the complement system and mast cel