https://daratumumabinhibitor.c....om/curbing-antibioti
2-Heptyl-3-hydroxy-4(1H)-quinolone (PQS), a compound from P. aeruginosa, functions as both a quorum sensing (QS) regulator and a potent metal chelator to induce appearance of pyoverdine and pyochelin which are associated with high-affinity iron transport systems. A possible dual-acting antibiofilm strategy needs particles made to affect iron uptake plus the QS system of P. aeruginosa. A number of 2-substituted 3-hydroxy-1,6-dimethylpyridin-4-ones are created, synthesized,