https://www.selleckchem.com/pr....oducts/bay-11-7082-b
Results NOB demonstrated an inhibitory effect on PCa cell growth and LNCaP cells were more sensitive to NOB than PC-3 cells due to androjen receptor status. Furthermore, NOB alone could suppress TLR4/TRIF/IRF3 and TLR9/IRF7 signaling pathways through the downregulation of their associated pathways (mRNA and related protein levels) and the release of IFN-α and IFN-β compared to LPS or CpG-ODN stimulated PCa cells.Conclusions NOB potentially inhibited TLR4 and TL9-dependent signaling pathway in PCa cells. However, the effi
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