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There were statistically significant differences for time to sedation with midazolam compared to olanzapine ( =0·03) and haloperidol ( =0·002). Adverse event rates were similar across the three arms. Dystonia ( =1) and cardiac arrest ( =1) were reported in the haloperidol group. Midazolam resulted in faster sedation in patients with undifferentiated agitation in the emergency setting compared to olanzapine and haloperidol. Midazolam and olanzapine are preferred over haloperidol's slower time to sedation and potential for cardiovascular a