https://www.selleckchem.com/pr....oducts/ly2801653-mer
HAS and HBS were found in the plasma of animals administered with DKT and persisted up to 2 h after the administration. This is the first report on telemetry demonstrating that DKT exhibited contractile effects on the dog's internal anal sphincter. The increased anal pressure and improvement of fecal incontinence symptoms observed in previous clinical studies may have been based on this sphincter contraction. This is the first report on in vivo telemetry demonstrating that DKT exhibited contractile effects on the dog's inte
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