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It is also shown that the present DSCF method can yield fast and robust convergence with near-linear scaling in performance with increase in system size. © 2020 Wiley Periodicals, Inc.Mycodextran-also known as nigeran-is an unbranched polysaccharide made of α-d-glucopyranose units alternatively connected by (1 → 3) and (1 → 4) glycosidic linkages produced intracellularly by Aspergillus niger and Penicillium crustosum. In this work we examine possible enforced conformational transitions in the glucopyranose rings in the nigeran oligosacc