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New potential therapeutic targets also are suggested as well as the likely timing of their pathogenic engagement. Due to public concerns about deleterious biological consequences of radiofrequency electromagnetic fields (RF-EMF), the potential effects of RF-EMF on the central nervous system have received wide consideration. Here, two groups of C57BL/6 mice, aged 2 and 12months, were exposed to 1,950-MHz RF-EMF at a specific absorption rate of 5.0W/kg for chronic periods (2hr/day and 5days/week for 8months). Behavioral changes were then