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The rs2228230T allele decreased the expression of PDGFRA by reducing the stability of its mRNA and protein as well as the signaling activity of the MAPK and PI3K/AKT pathways. PDGFRA mRNA and protein expression was significantly reduced in AM tissues with the rs2228230T allele. The progression-free survival and overall survival of AM patients with the rs2228230T allele were significantly longer than those of patients with the CC genotype. Conclusion Our study indicated that rs2228230T can reduce the expression of PDGFRA and downstream s
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