https://www.selleckchem.com/Proteasome.html
N-acetylcysteine is a thiol-containing antioxidant, which has shown otoprotective effects in in-vitro as well as in-vivo models of cisplatin induced hearing loss. Systemic administration of antioxidants, however, is associated with the major potential drawback of interference with the tumoricidal effect of cisplatin. This therapeutic limitation can be overcome by local intratympanic injection of the antioxidant N-acetylcysteine, which results in very restricted systemic uptake of the drug, whilst intracochlear drug levels are substantially hi
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