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The polyphenol-rich plant from propolis inhibit S. mutans development and biofilm formation, as well as the genes taking part in virulence and adherence, through the inhibition of glucosyltransferases. Nevertheless, because the substance composition of propolis is highly variable and complex, the procedure of their antimicrobial action therefore the energetic compound tend to be controversial and never totally recognized. Caffeic acid phenethyl ester (CAPE) is