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SUBA™-itraconazole (S-ITZ) which releases drug in the duodenum compared to conventional ITZ (C-ITZ) in the stomach were compared in two PK studies a 3-day loading dose and a 15-day steady-state. These were crossover, oral bioequivalence studies under fed conditions in healthy adult volunteers. In the loading dose study, C-ITZ (2x100 mg) and S-ITZ (2x65 mg) were administered TID for 3 days and once on day 4 (N=15). For the steady-state study, C-ITZ (2x100 mg) and S-ITZ (2x65 mg) were administered BID for 14 days and a last dose 30min afte