https://www.selleckchem.com/pr....oducts/sodium-ascorb
The purpose of the present study was to examine the protective action and mechanisms of quercetin on the blood-brain barrier (BB in rats subjected to transient middle cerebral artery occlusion (tMCAO) and reperfusion. Quercetin (10, 30, 50 mg/kg) was intraperitoneally administered at the onset of reperfusion. The results showed that quercetin significantly reduced cerebral infarct volume, neurological deficit, BBB permeability and ROS generation via Sirt1/Nrf2/HO-1 signaling pathway. Moreover, EX527, a selective inhibitor of
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