https://www.selleckchem.com/pr....oducts/oxidopamine-h
Treatment with the clinical ATR kinase inhibitor VX-970 induced apoptosis in MYB-positive ACC cells and growth inhibition in ACC PDXs. To our knowledge, ATR is the first example of an actionable target downstream of MYB that could be further exploited for therapeutic opportunities in ACC patients. Our findings may also have implications for other types of neoplasms with activation of the MYB oncogene.STUDY DESIGN This is a retrospective review. OBJECTIVES To validate the concept of "non-locality" to explain cases of Spi
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