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7% (14/19) of deliveries that were not covered by prophylaxis compared with 54.2% (32/59) of deliveries that were (OR = 2.36, 95% CI 0.75-7.4. Neonatal bleeding complications were reported in 10.0% (8/8 of deliveries. In all (6/6) deliveries with neonatal bleeding complications wherein the presence of alloantibodies was investigated, either antiplatelet or anti-HLA antibodies were detected. DISCUSSION/CONCLUSION Menstrual and particularly obstetrical bleeding problems frequently occur in women with IPRD, based on small case reports