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However, the incidence of DIAR in this study was much higher than that in humans, suggesting that dextran 40 should not be used in domestic pigs. Hyponatremia and syndrome of inappropriate antidiuretic hormone (SIADH) is a potentially fatal adverse effect of antidepressants (ADs) and antipsychotics (APs), although its frequency and onset time have not been well documented. To analyze the frequency and onset time of AD- or AP-induced hyponatremia/SIADH. We used plural data-mining techniques to search the US Food and Drug Administration Adv