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Nalmefene had a greater effect on ACTH and cortisol, compared with naltrexone. Both compounds also caused elevations in prolactin in males (females were not examined, due to the influence of menstrual cycle on prolactin). CONCLUSIONS This study suggests that both nalmefene and naltrexone have effects potentially due to κ-partial agonism in humans, as well as antagonist effects at μ-receptors. © 2020 John Wiley Sons Ltd.BACKGROUND Although pelvic floor dysfunction (PFD) has a multifactorial etiology, pregnancy and childbirth are co
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