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rd the secondary brain injury of ICH. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are highly effective for glycaemic control and weight loss in patients with type 2 diabetes (T2D). In this retrospective, observational study, we analysed glycated haemoglobin (HbA1c) and weight following switching to semaglutide from any other GLP-1 RA, using US electronic health records and prescription data. Adults (≥ 18years old) with T2D required at least one prescription for injectable semaglutide at index date (treatment switch), at least